From a DVM:
“There is NO RULE on avoiding vaccines for our affected dogs. Exception: Generally speaking, dogs with myasthenia gravis are not vaccinated after diagnosis, but EVERY SITUATION MUST BE INDIVIDUALLY analyzed. I can’t stress this enough.

The whole subject of vaccines has been evolving and changing the past several years, and for good reason. There is plenty of data that suggests that overvaccination is harmful. We do not yet even know all of the long term effects. Not vaccinating, or undervaccinating is risky, too. The right decisions can only be made after a thorough review of your particular dog’s situation. That means your activities, places you go, contact with other animals, and the CURRENT communicable disease information in the locale(s) where you live, play, commute, etc. Titers are helpful, but not conclusive. I do shy away from ANY “one size fits all” approach, though. Adult healthy dogs generally do not require vaccines, and I can seldom see a need for yearly vaccines. There are exceptions to everything, though.

My own rule of thumb for my dogs, in my region, and with our activities, is core vaccines and Rabies every three years (latter is required). After senior years, even less often. Exceptions: rattlesnake vaccine and avoidance clinics, and right now: parvo and corona are rising again in California to the extent there are health alerts going out to the DVM profession and shelters, I think, also. I have a friend with a Leonberger puppy, vaccinated, all proper precautions taken, who contracted parvo, fought for her life, and is now on the mend. Scary!

Don’t shortcut this decision! Know your locale, your dog, and have informed discussions with your DVM – then decide. You have to do the risk/benefit analysis.”